Early detection of inflammation-prone STEMI patients using the CRP Troponin Test (CTT)

Abstract Background Elevated concentrations of C-reactive protein (CRP) early after acute coronary syndrome (ACS) may reflect the magnitude inflammatory response to myocardial damage and are associated with worse outcome. However, routine measurement both CRP cardiac troponin simultaneously in setting ST segment infarction (STEMI) is not used broadly. Here, we sought identify characterize individuals who prone an elevated following STEMI using Troponin test (CTT) determine their short- long-term Material methods We retrospectively examined 1,186 patients diagnosis STEMI, had at least two successive measurements combined (up 6 hours apart), all within first 48 admission. Chi-Square Automatic Interaction Detector (CHAID) tree analysis which parameters, timing (baseline vs. serial measurements), cut-offs should be predict mortality. Results Patients high (above 90th percentile, >33mg/L) higher 30 day- all-cause mortality rates regardless status or below 118,000 ng/L); 14.4% vs 2.7%, p<0.01. Furthermore, levels on second highest 30-day compared rest cohort; 21.4% 3.7%, These also a median follow up 4.5 years 42.9% 12.7%, p<0.01 (Figure 1). Conclusions In conclusion, might detect increased risk for short-and STEMI. suggest future use Troponin-test as potential marker inflammatory-prone outcomes ACS. This sub-type benefit from anti-inflammatory therapy such colchicine anti-IL-1β agents. Funding Acknowledgement Type funding sources: None.